Institution: ICCOM
Departement: DSCTM
Typology: Academic collaboration, Facility, Skill
Location: Via Moruzzi 1 56124 Pisa
Contacts:
- Elisa Passaglia
Description:
The PMC_lab at ICCOM, led by researchers Serena Coiai, Francesca Cicogna, and Elisa Passaglia, has extensive experience in the synthesis and characterization of functional nanoparticles designed for advanced polymer-based materials. In recent years, the team has developed expertise in preparing phosphorene nanoparticles through liquid-phase exfoliation processes. These nanoparticles are stabilized using decoration effects and are embedded within biocompatible and biodegradable polymer phases or micelles. The nanoparticles have been characterized to evaluate their potential in generating singlet oxygen upon irradiation, assessing their applicability in photodynamic therapies. Preliminary results, collected in collaboration with the Nanoscience Institute of CNR, have been promising, especially where findings indicate potential for disaggregation or inhibition of amyloid aggregation in insulin. Additionally, a study examining their antibacterial properties is currently underway. **Applications** 1) Photothermal and photodynamic therapies 2) Drug delivery 3) Antibacterial properties 4) Inhibition of fibril aggregation **Instrumentation** Ultrasonic processor Hielscher UP220 St. Spectrofluorometer Horiba FluoroMaxPLUS-TCSPC. UV-Visible spectrophotometer Jasco V-750 equipped with an integrating sphere. FT-IR spectrophotometer Perkin Elmer Spectrum Two equipped with the ATR accessory (diamond crystal). SEC Agilent Technol. 1260 Infinity. Thermogravimetric analyzer TG/DTA 7200 Exstar; Differential Scanning Calorimetry DSC 4000 PE, suitable for OIT tests. INTRON (5960 series). Honle UVACUBE 400 irradiation chamber with different emitting lamps (H 400F/2 and F 400F/2 lamps); Solar lamp; Low-pressure plasma chamber Tucano model Gambetti Kenologia **Publication** 1) Passaglia, E.; Sgarbossa, A. Innovative Phosphorene Nanoplatform for Light Antimicrobial Therapy. Pharmaceutics 2023, 15 2748. https://doi.org/10.3390/pharmaceutics15122748 2) Carla Caponio, Agata Costanzo, Serena Coiai, Francesca Cicogna, Emanuela Pitzalis, Silvia Borsacchi, Giulia Lorenzetti, Emilia Bramanti, Alessia Papalini, Antonella Battisti, Antonella Sgarbossa, Elisa Passaglia,“Cyrene- and water-based exfoliation of black phosphorus for potential nanolayer-mediated disaggregation of insulin fibrils” FlatChem, 45, 2024,100665, https://doi.org/10.1016/j.flatc.2024.100665 3) Agata Costanzo, Carla Caponio, Serena Coiai, Francesca Cicogna, Giulia Lorenzetti, Emanuela Pitzalis, Franco Dinelli, Enrico Berretti, Stefano Caporali Andrea Pucci, Elisa Passaglia "Integrating water-exfoliated phosphorene into poly(lactic-co-glycolic) acid: stability and photoactivity potential” submitted
Team:
- Elisa Passaglia (elisa.passaglia@cnr.it)
- Serena Coiai (serena.coiai@cnr.it)
- Francesca Cicogna (francesca.cicogna@cnr.it)